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July 24 Breaking newseven though it's still a challenge and certainly a very controversial subject to generate human beings from any type stem cells, apparently it works with mice!
two groups in China just reported making mice from induced pluripotent stem cells (iPS): one from CAS (State Key Laboratory of Reproductive Biology) published a letter in Nature, and the other from Chinese Academy of Medical Sciences and Peking Union Medical College made it to the also prestigious Cell Stem Cell.
here's the Nature news:
Stem cells: Live mice from fibroblast
Stem cells induced from somatic cells can be as pluriopotent as stem cells extracted from embryos, research published online by Nature has demonstrated this week. A team from China created induced pluripotent stem (iPS) cell lines from mouse fibroblasts, before showing that these cells could go on to generate fertile live mouse pups, the first born of which they named Tiny.*
Qi Zhou, Fanyi Zeng and colleagues report the generation of 37 iPS cell lines, three of which produced 27 live offspring by tetraploid complementation. One of these, a 7-week-old male, went on to impregnate a female and produce young of its own. *In Chinese "小小“ written as "Xiao Xiao", which sounds like "Shau Shau".
full article in Nature:
"iPS cells produce viable mice through tetraploid complementation"
report in Cell Stem Cell:
"iPS cells can support full-term development of tetraploid Blastocyst-complemented embryos"
December 30 jp tv好久没有(不用快进)看日剧，但是硬盘告急，美剧的质量/空间ratio比较高，于是决定从那几十部存了又没看的日剧下手.............周末两个晚上竟然搞定两部...........
bloody monday 才播完的，当时因为被海报上三浦同学的侧面震撼到于是打算看看要不要追，主题是hacker+virus+terrorist+patriot+nuclear weapon(?)........前两集看的我为里面hacking的那一显示屏code欲罢不能想说真是很久没有让我能一集一集追的日剧了结果第三集就没看下去.......不过等完结了一口气看完也还是不错的，虽然播放期间也有剧透无数不过悬念还是有一点的，比较起来的话日本在高科技反恐这个方面和美国的同类剧还是没办法比的，还有就是演员的话........大概普遍日系演员演戏比较用力......更不要说年轻的一代了......倒是佐藤sato君没有我想象中那么糟糕，本来以为特摄拍多了也会演技比较夸张的，这部里面倒还好——当然一方面也是因为他没有什么戏份....... 男一号haruma君的演绎.......也还好吧........毕竟人家才18岁、要求不能太高.....中间有一场哭戏是在看到同学染病即将身亡却仍在鼓励自己的时候，本来是很感动的场面结果我被他突然用手捂住嘴哭泣的乙女状呕到了.....想说你看旁边的女生都没有像你这样啊.........不过临近ending时那个几乎放弃一切静静流下泪的场景还是很加分的...... 回想起来原来整部剧haruma君给印象最深的就是那个海报上的侧面了........ 成宫宽贵的J还不错，那种很嚣张的leader姿态由他演来没想到还不错，然后扮纯良数学家的时候也还比较可信........不过为什么会喜欢喝melon soda啊？！那种颜色很可疑的东西怎么能放进嘴里啊........... 意料之外女一号(?)虽然开始没有很喜欢却是越看越舒服，喜欢她那种慢悠悠一切尽在掌握的态度，还有声音也很性感....... 整部剧最后也算有点意料之外，就在大家都以为东京是要毁在virus手上却没有想到最终boss是nuclear weapon.......其实也没差，反正都是要被毁掉的......orz.... ....虽然期间吐糟无数、纠结bug无数....总的来说还是可以一看的剧........音乐不错，听井筒昭雄做的tv音乐也不是第一次了。主题曲的乐队flumpool也很棒，走britrock风让我想到一点点TBG，unreal整张专辑都很赞 貧乏男子
选中这部看是因为剧情不是我喜欢的型可以随便看看就删掉解救硬盘........当初下这部也只是看到小栗主演而且号称"小栗旬打破形象上演sports装show"引得我好奇........当然另外就是正好TVBT做了这部...... 于是开始看，看完第一话前5分钟，证实：1果然不是我喜欢的类型；2小栗果然tension高到那5分钟内竟然来回有跑到一万米。然后立刻转去最后一话的最后5分钟，想说看完这5分钟就可以删了～不料，在最后5分钟的场景看到了很眼熟的人(shun君除外)....于是暂停又倒回几秒反复看了，终于确认——这个不是刚刚在BloodyMonday里的haruma君吗？！我也没有很迷他为什么接连两部剧里都有他啊........于是wiki了一下cast，果然有三浦春马的名字而且还是主役——本来还想只看有他出现的话数就好了不料这个家伙从第一话第6分钟开始一直悠悠演到最后一话倒数第4分钟........ 一边快进一边看，有haruma出场就停下来，不过这个家伙的场景也都是和小栗对手戏，看了一会儿渐渐想起来当时这部剧在播出的时候我其实看过某一话的图透，那个作者yy这两位我当时也没什么感觉只觉得小栗以外的那只的确是清秀可爱配小栗稍稍可惜了点.....原来那个时候就见过haruma了....再看一会儿，连我一向不yy真人couple的都忍不住吐糟——拜托两位不要一对戏就深情对视眼泪汪汪了好不好>_< 小栗那样表情有点惨不忍睹、haruma那样还是比较有杀伤力的啊～不过那个没有事干就冲去某人公寓问候某人、送给/接受某人东西、以某人为日记主题、竟然还因为心疼某人打工晚归辛苦而主动替人家做饭的人是谁啊？！haruma你的角色好歹在剧中是有暗恋女生的、你干嘛在邻居小栗君面前那么人妻样啊！！！这个和BM里面也差太多了吧........还是说其实这种柔顺乙女态其实才是本性？！果然在BM里面让你拯救东京是太难为你了........ 看完，感叹：
小栗你果然穿了很多套颜色搭配诡异的运动服，好在身材高挑所以视觉效果还有得挽救； 第一次看山田优的戏，意料外的喜感很不错....这部剧里很多演员都喜感不错的； 整部戏以我的胃口来看tension过于高了，小栗体力堪比樱木花道了，完全以跑代走，倒是不浪费那么多运动装。不过既然是热血主题当然就少不了感动戏，有一些细节还是蛮感人的，父子情和母子情那里，还有小栗真的是很辛苦赚钱还债的场景 最后....haruma君.....虽然不愿意承认...但....比起BM...你果然还是适合回归本性的小媳妇状啊....... October 15 H. Y.i saw howard young today. the millionaire who suffers from pancreatic cancer, the man who told us two years ago that he would personally sponsor us if we didn't get our NIH funding.
he came here today. bossman wanted to introduce me to him, but i ducked.....if it's just about talking, bossman is better at bsing than me.
he was only outside our lab for half hour maybe. he and three PIs were just talking outside our computer room. his voice was a little weak, probably because of the chemo session he had yesterday.
truth is, i would've felt guilty facing him, because i know i'm not, and we're not doing our best in this project. the way he looked today just reminded of...everything i've been trying to get over with for the past two months.
there are hundreds of labs out there doing cancer biomarker research for decades, and NIH funds probablly more than half of them, yet still today we are using CA19-9, PSA, BRAC etc. for diagnosis, which creat false positive or false negative results all over the place.
we brag about medical development and scientific technology advancing all the time, and we can say that we're able to save millions of people who would've not even standed a chance to live 10 years ago. the reality is, there's always challenge in front of us, and we can not save everybody.
i have to realize that and keep that in mind, otherwise the frunstration alone would kill me.
i'm aware of that i'm not, and our lab is not obligated to him. after all, it's not his money we're wasting here......it's just his life...... October 07 .............i guess no matter how much you love your job, there's always some time that you just want to get away from it and not thinking about it.....
it's nothing contradictive, it's just....when you keep doing one thing for a long time, it becomes regular, becomes routine, and you need a change, a refresment, so that after which you can go back to work and start feeling the passion again.....
i haven't gotten to that place, well....not yet. but i have no doubt that someone, who's been in the same line of work for 20 years, would want to go to someplace once a while where he doesn't need to be reminded of his job at all, even though he excels in his field, even though he's still passionate about it after 20 years.
.....from time to time, i do wish that fariy tales never end and we all live in a perfect world........
September 28 house"Cancer stem cells are real. They explain everything. They're like embryonic stem cells. ......"
quote from "House M. D." season 5 episode 2, 00:34:34 to 00:34:40
thank you!!
how can you not love this show......
August 17 .....disappointing news.....one after another....
it's really not a good feeling...not being able to trust someone, especially someone that you used to have faith in....
everything seems to suck recently..... August 08 informed consentinformed consent is overrated. it actually doesn't even exist. without the specific knowledge and training, how informed can we be?
now i kind of understand why allan is so annoyed these days: financial problem, my bossman and this. and now he's out of the country.
well, i'm just glad that my bossman is not the only reason that pissed him off.
anyway, i'm all for Obama on this one. August 04 .....too upset to sleep last night....
how do you feel, knowing that there's nothing you can do to get him out of that hell?
helpless....useless....impotent.....?
all the above.....
then, welcome to my world. July 11 just read something....SCIENCE, this week's news: "......A new study has found that the most likely undergraduate alma mater for those who earned a Ph.D. in 2006 from a U.S. university was … Tsinghua University......" so now the Top 5 ranking for "the most fertile traning ground for US PhDs" is: Tsinghua Univ., Beijing Univ., Berkeley UC, Seoul National Univ. (South Korea), Cornell Univ., and Univ. of Michigan. hmmmmm....something interesting to know about.... June 13 ughhhhhh........dreamed about dead infants last night.........ughhhhhhh......they're actually more like un-fully-developed embryos, and they're in plastic bags labeled as "vital signs: 0".......
the second i woke up i went straight to bathroom and puked..........
it has escalated, my nightmares, from bloody crime scene to.....this.....
geez.....exactly how twisted am i....... June 12 再来.....又看了《伤城》和《投名状》，共同点就是都有takeshi小武同学......嗯，ms女主角也是同一人.....嘛，本来就是男人戏，女主角就作绿叶忽略了.....
除了小吴外，小武也是绝对国际级的男色艺人了，比小吴还要资历深些。从初出道的台湾搞笑烂片期、之后的日本隐身期，再到现在的完全回归中日港台火力全开时期，越来越有魅力。每年1-2部戏，力求每部都是精品的挑选剧本做法也很赞，虽然即使这样千挑万选也难免遇到口碑不一的作品——尤其是当那个导演大牌到让你觉得不接他的戏绝对会错失机会——这次算幸运了，至少和刘德华的合作没有像几年前那次.......
我是声控，看电影也是没有原声宁可不看的，所以投名状里听到刘德华的角色是用配音的有点不爽，不过如果他真用国语配我可能听了更别扭......李连杰的配音听不太出来，80％是专业配音的，小武和老徐皆是亲声上阵的，满好。感叹一下小武同学的语言天分，普通话、广东话、台语、日文、英文全都没问题，fluent，比小吴要强出台语和日文哦。说起来这两个人的声音都是那种deep voice，音质性感，发音也都是我喜欢的类型：小吴因为在美国长大所以说中文有卷舌音；小武因为曾经就读国际学校再加上爸爸是日籍所以也带有日式的卷舌音。
剧情方面，投名状是说清末山匪三兄弟的官兵养成记，虽然不是最喜欢的故事类型，不过文艺片出身的陈可辛能够将两军争战的场面拍成这样的气势也着实让人惊喜，虽然后面主要以单人为着眼点也可以理解。有点缺憾的是大哥、二哥、二嫂之间的感情纠葛有点牵强，可以明白导演的意图是给大哥加些人性化特征，但大哥二嫂间那个只凭一夜也稍稍嫌少了点。嘛，其实这个也不是更糟的，万一编剧在感情线上自暴自弃了把三弟也加上写出4P的狗血剧情就真是毁了.........这部戏总的来说满好，二哥被杀的场景和最后大哥三弟对峙的场面都不错。
伤城的话，题材是近期很爱的一种：有预谋犯罪。人性的复杂和黑暗真是永恒的主题～～～梁朝伟也是很中意的演员啊，内心戏很棒，这次的剧情和戴上眼镜斯斯文文的伟仔真是配极了。这次两人的独白都不少，都有小小王家卫风。刘伟强是很有实力的导演了，故事又是擅长的警界黑道，挑的演员也棒，整部戏质量上乘啊。虽然看完后有点小小失望，觉得梁朝伟的角色其实可以更黑暗一点的，剧中是因幼年家庭毁灭而复仇的很人性化的反派，其实可以把幼年家破人亡作为一个stresser，让角色的性格更加偏执，在遇到和当年类似的案件时便会自己动手杀害嫌疑人，这样几次后再被小武同学发现，然后再自杀好了。不过这样的话估计一部电影也不够拍了.....不如三部曲好了......
June 04 movie在上海等签证时很无聊，就把以前积压的一些电影看了——真是很久没看香港电影了，听广东话竟然也有小小亲切感
看放逐exile，一开篇就大概猜到结尾应该是全灭的——香港的黑帮片——不过过程中还是看的很愉快，看几个黑衣黑超黑面酷到家的家伙帮人家煮饭做菜还兼收拾房间修补家具实在是很有笑果，后面还有很多细节把几个印象中应该只识揸枪的杀手人性化了很多，结尾那个在一罐饮料抛起落下的时间内众人枪战至全灭的场景也很有导演signature的感觉。演员没话说，黄秋生、吴镇宇、张耀扬、林雪都是在黑帮片中浸淫已久，配角也都是很出彩的演员了，被任贤齐的演出小小惊艳了一下——其实不唱歌专门去香港电影客串古惑仔类的配角也是不错的选择嘛，搞不好哪天出个最佳男配角也说不定哦。背景音乐也是大爱，鼓点配电子乐再加上适当的煽情效果，和整套戏很配合。看完才发现原来竟然是06年的戏了——我果然积压了不少........香港的黑道片算是很独特的一种形式了，本土的感觉哪里都学不来的，拍的多了自然套路就多了，很多看起来都似曾相识，即使如此高产，杜琪峰的黑道片还是很值得期待的，演员方面——与其说他会选角不如说他善发掘塑造，情节方面既重视细节又能让整部戏有一气呵成的感觉。好像其实他的爱情小品也很出彩。
exile之后是门徒protege，说实话当初下这部戏完全是因为小吴同学美色，再就是想看看两代偶像交接班。看完的第一感觉就是：导演大牌果然就是号召力强，随便一个配角都是有份量的。其实对尔东升的爱情戏还是很喜欢的，尤其当年的新不了情，后来的不了情也不错不过有食旧作的嫌疑，不过对他的犯罪题材的戏就有点.....缺乏张力.......之前那部旺角黑夜我连看都没看完竟然他也会因为那部片被提名好几个奖项，真是替其他竞争者不抵啊～～比如说因功夫提名滴周生......不过这次这部还不错了，又是小吴主演，卧底、毒品，虽然看到刘德华的皱纹对着风华正茂的小吴有小小唏嘘。还有就是果然他没有浪费掉小吴的美色，几分钟的亲热戏做足分量——感觉小吴和当年dicaprio的遭遇类似：是导演都不会放过他的身体滴～～
然后看的天堂口——事实证明看这部戏尤其是在看完两部名家作品之后看这部戏实在是失策。虽然之前看过网上吐槽，不过小吴的魅力加上blood brothers这么有兄弟爱的诱人片名于是我还是看了，结果看了二十多分钟就开始快进了，即使小吴的国语听起来也很性感。三兄弟看起来小吴是真正男一号，有点遗憾杨佑宁同学我初看几乎认不出来，果然被另两位一比就湮没了，虽然刘烨也没有印象中清秀了。一边快进一边就开始琢磨这三位演员，突然发现其实三人还满多共同点的：都有主演过同性题材电影——香港、台湾、大陆；而且ms在戏中都是bottom >o< 小吴那个其实top, bottom都有........不如这部戏叫blood gay brothers好了orz......
快进完这后还是呕了很久，觉得唯一亮点是舒淇那支歌。
为了洗目于是紧接着看了周生的长江7号，嘛......笑料还是有的，情节还是有的，演技还是有的。最后看到坠楼那段还是有点意外的，没有料到真是有科幻到那么夸张，然后看到醒来的小狄抱着爸爸哭着说"不要离开我"的时候立刻就掉眼泪了，很奇特的感觉。其实刚听说时就知道是自己不喜欢的题材，与其说是科幻不如说是童话，说起来其实功夫也很童话哦，果然周生心中还是小孩子吗？不过亲情的故事对我基本上是杀必死的，之前也怀疑过周生出演人家老爸会不会欠缺说服力，现在看来还ok。不过科幻也好、童话也罢，拜托周生你好歹也给自己多点戏份吧～～搞得我整部戏都在看小孩扮大人，我宁可看你在工地上的打工场景啊～～～ April 14 burstthis is such a crap!!
why am i even going through this?? what's the point!
everything has been so aggravating recently, or at least that's how i feel....i'm getting less patient and tolerating.....
how the hell did they publish that paper?! seriously, "who did they sleep with!"
....i'm so on the verge of committing murder....... March 18 又是一年3.18几大论坛的庆生礼物也发了、庆生游戏也玩了、庆生楼也踩了
这一年也是迷上某人的第二年了，第二次过3.18了
回顾一下，虽然一直在抱怨某人BL工作量或是全部工作量减少，其实仔细算算今年的工作量也是很可观的，虽然大部分作品是协役和龙套，但其实也满足了。
目前已经是无论动画还是drama CD都是以他的作品为中心了，不敢想象如果真的听不到他的声音了会怎样。
所以新的一岁里请好好爱护身体，继续和妻子、儿子一起幸福的享受生活，然后也请毫不吝啬的用或性感或温柔的声音和高超的演技诱惑fans吧。
三木さん，四十嵗，お誕生日おめでとうございます！
March 16 悲伤过度......且想杀人......之前只知道这一话有人牺牲，说实话真的以为会是alle，或者说是我希望是alle而不是lockon，现在看来......只见网上哭声一片.......sunrise及监督、脚本被诅咒、威胁等等.....
拜托某人，你生日就到了何必这样折磨fans呢......前一部钢铁三国志一共25话你于13话仙逝，这次一共50话你还没有撑到一半......钢三那种烂片也就算了，这次是gundam好不好，还欣喜终于某人也加入这部国民动画了结果第一季未完结就挂了......主角当成这样也未免太好欺负了.......
.....而且每次都是宫野做no.1主角的......莫非真的和他八字不合......
look on the bright side......there isn't any.......
 至少四月到十月，我不用纠结第一季完结第二季未开始了......到底要不要继续追第二季都是个问题......难道说只有在众人回忆时才能再次听到某人的声音了？？
.....除非......那个传说中的孪生兄弟(lockoff ??)来驾驶新的dynames——不要告诉我你们不打算重制dynames！！真的会死人的哦！！！
嘛.....我去关注crystal blaze算了......
edit take 1
刚才看到有人截了lockon最后时手伸向地球的图......这个男人至死不变的温柔啊......其实是很美的画面但一看就忍不住眼泪......
如果我再irrational一点大概现在就去犯罪了......
edit take 2
所谓"高达之所以为高达的时刻".......吗？
其实高达都是悲剧的吗.......开始有一点明白为什么可以成为全民追捧的作品了..... March 02 gundam有没有搞错？！21话竟然让lockon中了一剑？！水島和黒田是不是疯了？！
之前看剧透我还不相信，想说怎么可能让主角之一lockon瞎了呢，人家lockon可是观众投票选出的人气第一角色啊，高过官方的setsuna呀，结果08 G Festival才过一个月你们竟然就让no.1人气的lockon在动画里瞎了？！
真想去杀了监督和脚本，如果不是为了gintama就轰了sunrise！！！
本来剧情就被众fan骂脑残了，我虽然没觉得剧情有多差，不过对setsuna和tieria实在喜欢不起来.......基本上完全为了lockon坚持下去的，目前实在很泄气啊........ February 25 it's okayit's okay if you're tired, i know you probably are...tired of being brave and strong, mostly for us.
it's okay if you feel weak and sick, and in pain;
it's okay if you don't want to be positive;
it's okay to cry when the treatment is not working;
it's okay to be scared because we're scared, too;
it's okay to say 'i'm dying' to us, and to yourself.
it's okay if you don't want to hold on anymore, you don't have to worry about us, you don't have to worry if we're ready. we'll never be ready to let you go, but once you've decided, we will be there for you every step of the way.
because we love you, and because we'll miss you.
i want him to know that, except that i don't know how, or even if i could. |
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